Another way that psychoanalysis has changed according to Gilles Deleuze in Dialogues 11 is in terms of the theory.He says that:

The transition from the signifed to the signifier [means that] we no long for a signifier for supposedly signifiicant symptons ; if we look, on the contrary, for the signifier for symptons which would be no more than than its effect; if interpretation gives way to significance--then a new shift takes place. Psychoanalysis then has, in effect its own references and has no more use for an external 'referent'. Everything that happens in psychoanlysis in the analyst's consulting room is true. What happens elsewhere is derived or secondary.(p.86)